She's not exactly Mr. Prezbo, but on "New Girl" hyper-quirky actress Zooey Deschanel plays a a character named Jess who lives with three guys and is also an elementary school teacher. Occasionally, we get to see her doing something education-related, as in Episode 14 when Jess has to deal with a bullying student in her class and ends up apologizing to her principal after losing her cool:
Jess: I am so sorry, Tanya.
Principal Tanya: Don't be. I love it! Jess, you're a real teacher now.
Jess: What?
Principal Tanya: You're a kid-hater. You're one of us.
Jess: But I don't hate her.
Principal Tanya: Of course you don't.
Link to other lines from the show here. A review of the season from a teacher's perspective here.